一、动物模型相关文献荟萃分析
以“animal model”为关键词，在Pubmed（https://pubmed.ncbi.nlm.nih.gov/）进行检索，2022年共发表20,008篇文献。
2. 万方数据库收录的动物模型文献
以“动物模型”为关键词，在万方数据库（https://www.wanfangdata.com.cn/index.html?index=true）进行检索，2022年共发表2177篇期刊论文。使用万方数据库提供的文献检索结果分析工具，对2022年“动物模型”相关中文文献的关键词、作者、机构、学科等分析，结果见图1-5。
就文献发表关键词分布情况而言，相关的关键词包括动物模型、大鼠、小鼠、氧化应激、动物实验、网络药理学等（图1）。
图1万方数据库中“动物模型”相关中文文献的关键词分布情况
就文献发表作者分布情况而言，发表动物模型相关文献最高的学者包括王雅春、刘彦士等（图2）。
图2 万方数据库中“动物模型”相关中文文献的作者分布情况
就文献发表单位分布情况而言，发表动物模型相关文献最多的单位包括中医药大学第一附属医院、中国农业大学、北京中医药大学、广西中医药大学等（图3）。
图3 万方数据库中“动物模型”相关中文文献的单位分布情况
就文献发表学科分布情况而言，发表动物模型相关文献最多的学科包括医药卫生、农业科学、生物科学、工业技术等（图4）。
图4 万方数据库中“动物模型”相关中文文献的学科分布情况
就文献发表杂志分布情况而言，发表动物模型相关文献最多的杂志包括中国组织工程研究杂志、中国比较医学杂志、动物营养学报、中国实验动物学报等（图5）。
图5 万方数据库中“动物模型”相关中文文献的学科分布情况
二、2022.4-2022.8 PubMed数据库收录的动物模型相关文献
1.急性缺血性中风大型动物模型比较研究
参考文献：Taha A, Bobi J, Dammers R, et al. Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?. Stroke. 2022;53(4):1411-1422. doi:10.1161/STROKEAHA.121.0360502.从小鼠脾细胞中分离和扩增小鼠 γδT细胞参考文献：Williams L, Dery KJ, Lee WH, Li H, Shively JE, Kujawski M. Isolation and expansion of murine γδT cells from mouse splenocytes. J Immunol Methods. 2022;508:113322. doi:10.1016/j.jim.2022.1133223.从新生小鼠到老年小鼠乳腺干细胞基因表达特征的演变 参考文献：Huang X, Xu Y, Qian L, et al. Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice. Cell Death Dis. 2022;13(4):335. Published 2022 Apr 12. doi:10.1038/s41419-022-04777-x4.小鼠和人类之间保守的年龄相关区域表观遗传特征研究参考文献：Perez-Correa JF, Tharmapalan V, Geiger H, Wagner W. Epigenetic Clocks for Mice Based on Age-Associated Regions That are Conserved Between Mouse Strains and Human. Front Cell Dev Biol. 2022;10:902857. Published 2022 Jun 3. doi:10.3389/fcell.2022.9028575.年轻供体小鼠的粪便微生物群移植可改善老年小鼠的卵巢功能参考文献：Xu L, Zhang Q, Dou X, et al. Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice [published online ahead of print, 2022 May 30]. J Genet Genomics. 2022;S1673-8527(22)00157-6. doi:10.1016/j.jgg.2022.05.006
6. Fancb缺乏导致小鼠卵巢早衰研究
参考文献：Cen C, Chen J, Lin L, et al. Fancb deficiency causes premature ovarian insufficiency in mice† [published online ahead of print, 2022 May 20]. Biol Reprod. 2022;ioac103. doi:10.1093/biolre/ioac103
7. 压力相关的恐惧记忆获得障碍研究
参考文献：Nascimento EB, Dierschnabel AL, Lima RH, et al. Stress-related impairment of fear memory acquisition and disruption of risk assessment behavior in female but not in male mice. Behav Processes. 2022;199:104660. doi:10.1016/j.beproc.2022.1046608.超声介导的阿尔茨海默氏症衰老小鼠中生物效应研究参考文献：Balbi M, Blackmore DG, Padmanabhan P, Götz J. Ultrasound-Mediated Bioeffects in Senescent Mice and Alzheimer's Mouse Models. Brain Sci. 2022;12(6):775. Published 2022 Jun 13. doi:10.3390/brainsci12060775
- Fgfr2小鼠个体发育协方差模式研究
参考文献：Martínez-Abadías N, Heuzé Y, Wang Y, Jabs EW, Aldridge K, Richtsmeier JT. FGF/FGFR signaling coordinates skull development by modulating magnitude of morphological integration: evidence from Apert syndrome mouse models. PLoS One. 2011;6(10):e26425. doi:10.1371/journal.pone.002642510.大肠杆菌感染肥胖小鼠肠道免疫研究 参考文献：Cai D, Tian B, Liang S, et al. More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged by Escherichia coli. Front Vet Sci. 2022;9:851226. Published 2022 Jun 3. doi:10.3389/fvets.2022.85122611.遗传背景对肾病小鼠的影响研究参考文献：Bufi R, Korstanje R. The impact of genetic background on mouse models of kidney disease. Kidney Int. 2022;102(1):38-44. doi:10.1016/j.kint.2022.03.02012.白细胞介素10缺乏加重雄性小创伤性脑损伤研究参考文献：Gu Y, Dong Y, Wan J, Ren H, Koehler RC, Wang J. Interleukin-10 deficiency aggravates traumatic brain injury in male but not female mice. Exp Neurol. 2022;355:114125. doi:10.1016/j.expneurol.2022.11412513.NCSTN突变对小鼠毛囊成分的影响研究参考文献：Shi TW, Cao W, Zhao QZ, Yu HX, Zhang SS, Hao YB. Effects of NCSTN Mutation on Hair Follicle Components in Mice [published online ahead of print, 2022 Jul 15]. Dermatology. 2022;1-12. doi:10.1159/00052552614.人和小鼠肾单位发育研究参考文献：Schnell J, Achieng M, Lindström NO. Principles of human and mouse nephron development [published online ahead of print, 2022 Jul 22]. Nat Rev Nephrol. 2022;10.1038/s41581-022-00598-5. doi:10.1038/s41581-022-00598-515.大鼠食管吻合磁压技术研究参考文献：Zhang M, Shi A, Liu P, et al. Magnetic Compression Technique for Esophageal Anastomosis in Rats. J Surg Res. 2022;276:283-290. doi:10.1016/j.jss.2022.03.001
16. 肺动脉高压大鼠心房收缩行为研究
参考文献：Lookin O, Mukhlynina E, Protsenko Y. Contractile Behavior of Right Atrial Myocardium of Healthy Rats and Rats with the Experimental Model of Pulmonary Hypertension. Int J Mol Sci. 2022;23(8):4186. Published 2022 Apr 10. doi:10.3390/ijms2308418617.Vericiguat在大鼠和狗体内的药代动力学和质量平衡分布研究 参考文献：Janssen W, Schwarz T, Bütehorn U, et al. Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats. Xenobiotica. 2022;52(5):453-462. doi:10.1080/00498254.2022.2082899
18. 光损伤白化大鼠视锥细胞研究
参考文献：Benthal MC, McKeown AS, Kraft TW. Cone Photoreceptor Loss in Light-Damaged Albino Rats. Int J Mol Sci. 2022;23(7):3978. Published 2022 Apr 2. doi:10.3390/ijms23073978
1.人类前交叉韧带断裂自发动物模型参考文献：Binversie EE, Walczak BE, Cone SG, Baker LA, Scerpella TA, Muir P. Canine ACL rupture: a spontaneous large animal model of human ACL rupture. BMC Musculoskelet Disord. 2022;23(1):116. Published 2022 Feb 5. doi:10.1186/s12891-021-04986-z2.n6-OHDA诱导新生大鼠模型参考文献：Stauch CM, Fanburg-Smith JC, Walley KC, et al. Animal model detects early pathologic changes of Charcot neuropathic arthropathy. Ann Diagn Pathol. 2022;56:151878. doi:10.1016/j.anndiagpath.2021.1518783.B型胱氨酸尿症FVB/NJcl小鼠模型 参考文献：Sasaki H, Sasaki T, Hiura K, Watanabe M, Sasaki N. A mouse model of type B cystinuria due to spontaneous mutation in FVB/NJcl mice [published online ahead of print, 2022 Aug 21]. Urolithiasis. 2022;10.1007/s00240-022-01356-9. doi:10.1007/s00240-022-01356-9
4. 退行性脊柱侧凸小鼠模型
参考文献：Hu Z, Tang Z, Kiram A, et al. The Establishment of a Mouse Model for Degenerative Kyphoscoliosis Based on Senescence-Accelerated Mouse Prone 8. Oxid Med Cell Longev. 2022;2022:7378403. Published 2022 Jul 20. doi:10.1155/2022/7378403
5. 败血症免疫抑制小鼠模型
参考文献：Wang N, Lu Y, Zheng J, Liu X. Of mice and men: Laboratory murine models for recapitulating the immunosuppression of human sepsis. Front Immunol. 2022;13:956448. Published 2022 Aug 5. doi:10.3389/fimmu.2022.9564486.肝实质损伤和再生小鼠模型 参考文献：Du Y, Zhang W, Qiu H, et al. Mouse Models of Liver Parenchyma Injuries and Regeneration. Front Cell Dev Biol. 2022;10:903740. Published 2022 May 5. doi:10.3389/fcell.2022.9037407.牙周炎大鼠模型参考文献：Gao J, Cai S, Wang Z, et al. The optimization of ligature/bone defect-induced periodontitis model in rats [published online ahead of print, 2022 Jun 3]. Odontology. 2022;10.1007/s10266-022-00715-7. doi:10.1007/s10266-022-00715-78.食管胃吻合口狭窄大鼠模型 参考文献：Li N, Fei X, Li C, Zhao T, Jin H, Chen H. A Rat Model of Esophagogastric Anastomotic Stricture [published online ahead of print, 2022 May 23]. Eur Surg Res. 2022;10.1159/000525168. doi:10.1159/0005251689.新生大鼠神经转移模型 参考文献：Sporer ME, Aman M, Bergmeister KD, et al. Experimental nerve transfer model in the neonatal rat. Neural Regen Res. 2022;17(5):1088-1095. doi:10.4103/1673-5374.32485110.体积性肌肉损失大鼠模型参考文献：Dolan CP, Dearth CL, Corona BT, Goldman SM. Retrospective characterization of a rat model of volumetric muscle loss. BMC Musculoskelet Disord. 2022;23(1):814. Published 2022 Aug 26. doi:10.1186/s12891-022-05760-511.前列腺癌大鼠模型 参考文献：Bosland MC, Schlicht MJ, Horton L, McCormick DL. The MNU Plus Testosterone Rat Model of Prostate Carcinogenesis. Toxicol Pathol. 2022;50(4):478-496. doi:10.1177/01926233221096345
12. 慢性脊髓受压大鼠模型
参考文献：Miura M, Furuya T, Hashimoto M, et al. Differences in the expression of myelopathy in a rat model of chronic spinal cord compression [published online ahead of print, 2022 Aug 22]. J Spinal Cord Med. 2022;1-9. doi:10.1080/10790268.2022.2111048
13.小鼠尾动脉吻合模型
参考文献：Wu XQ, Liu HR, Yu ZY, et al. A Super-Microsurgery Training Model: The Mouse Caudal Artery Anastomosis Model. Front Surg. 2022;9:841302. Published 2022 Apr 7. doi:10.3389/fsurg.2022.84130214.糖蛋白Ib-IX小鼠模型 参考文献：Ware J. Murine models of glycoprotein Ib-IX. Platelets. 2022;33(6):811-816. doi:10.1080/09537104.2021.202211515.甲亢小鼠模型 参考文献：Zhang M, Jiang W, Lu G, Wang R, Lv Z, Li D. Insight Into Mouse Models of Hyperthyroidism. Front Endocrinol (Lausanne). 2022;13:929750. Published 2022 Jun 22. doi:10.3389/fendo.2022.92975016.缺血性脑卒中食蟹猴模型 参考文献：Ye J, Shang H, Du H, et al. An Optimal Animal Model of Ischemic Stroke Established by Digital Subtraction Angiography-Guided Autologous Thrombi in Cynomolgus Monkeys. Front Neurol. 2022;13:864954. Published 2022 Apr 25. doi:10.3389/fneur.2022.86495417.猕猴耳鸣动物模型 参考文献：Rogenmoser L, Kuśmierek P, Archakov D, Rauschecker JP. The blinking eye as a window into tinnitus: A new animal model of tinnitus in the macaque. Hear Res. 2022;420:108517. doi:10.1016/j.heares.2022.10851718.应激性干眼症非人灵长类动物模型 参考文献：Gong L, Guan Y, Cho W, et al. A new non-human primate model of desiccating stress-induced dry eye disease. Sci Rep. 2022;12(1):7957. Published 2022 May 13. doi:10.1038/s41598-022-12009-719.自闭症模型狨猴模型参考文献：Nakagami A, Yasue M, Nakagaki K, Nakamura M, Kawai N, Ichinohe N. Reduced childhood social attention in autism model marmosets predicts impaired social skills and inflexible behavior in adulthood. Front Psychiatry. 2022;13:885433. Published 2022 Jul 25. doi:10.3389/fpsyt.2022.885433
20. 辐射诱发的小鼠颞下颌关节损伤模型
参考文献：Zhang P, Yao L, Shan G, Chen Y. A model of radiation-induced temporomandibular joint damage in mice [published online ahead of print, 2022 Apr 27]. Int J Radiat Biol. 2022;1-10. doi:10.1080/09553002.2022.2069298
21. 原发性痛经小鼠模型
参考文献：Hong F, He G, Zhang M, Yu B, Chai C. The Establishment of a Mouse Model of Recurrent Primary Dysmenorrhea. Int J Mol Sci. 2022;23(11):6128. Published 2022 May 30. doi:10.3390/ijms2311612822.唐氏综合征听力障碍小鼠模型 参考文献：Chen GD, Li L, McCall A, et al. Hearing impairment in murine model of Down syndrome. Front Genet. 2022;13:936128. Published 2022 Aug 4. doi:10.3389/fgene.2022.936128 图片均来源于网络
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